The great Thomas Lennon confirmed via Twitter:
Reno 911! was cancelled at 1:30 pm today. Won't be wearing the shorts again.
Spanning 88 episodes and a feature film, the series featured numerous players from The State as well as other familiar faces from the world of funny.
Also notable, it was one of those rare comedies that had a series of licensed Halloween costumes (pictured) made for it. It will be missed.